The National Human Genome Research Institute's cost tracking of genome sequencing relied on Moore's Law, but the governance over how that benchmark was actually applied needs to be crystal clear. Where is the RACI matrix showing who was accountable for validating its relevance, especially over two decades of rapid change? Without documented sign-off on the specific methodology and a change management process for adjustments, it’s just a loose comparison, not a foundational informational context. For example, if semiconductor physics shifted, was there an explicit procedure to re-evaluate the utility of Moore's Law for biological scaling, or did they just keep using it as-is?